ENHANCING CHEMOIMMUNOTHERAPY FOR COLORECTAL CANCER WITH PACLITAXEL AND ALANTOLACTONE VIA CD44-TARGETED NANOPARTICLES: A STAT3 SIGNALING PATHWAY MODULATION APPROACH

Chemoimmunotherapy has the potential to enhance chemotherapy and modulate the immunosuppressive tumor microenvironment by activating immunogenic cell death (ICD), making gruvi golden lager it a promising strategy for clinical application.Alantolactone (A) was found to augment the anticancer efficacy of paclitaxel (P) at a molar ratio of 1:0.5 (P:A)

Organophosphate pesticides are widely used in agriculture, leading to soil, water, and food contamination.Among these compounds is Dichlorvos [O,O-dimethyl O-(2,2-dichlorovinyl)phosphate, DDVP], which is listed as a highly toxic compound by the Environmental Protection Agency and World Health Organization.Exposure to DDVP can result in nervous, res

Background: Computational simulations of the E-field induced by transcranial magnetic stimulation (TMS) are increasingly used to understand its mechanisms and to inform its administration.However, characterization of the accuracy of the simulation methods and the factors that affect it is lacking.Objective: To ensure the accuracy of TMS E-field sim

The role of shunt placement is to divert cerebrospinal fluid (CSF) from within the ventricles to an alternative location most commonly peritoneal space.Ventriculo Peritoneal Shunt (VPS) is associated operation igloo white with many complications viz over drainage, valve failure, breaking of catheter, catheter obstruction, coiling of catheter, spont